Structure identification of Euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway.
نویسندگان
چکیده
In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC(50) values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.
منابع مشابه
Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway
Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. This article focuses on the cytotoxic activity of Euphorbia factor L2 against lung carcinoma A549 cells and the mechanism by which apoptosis is induced. We analyzed the cytotoxicity and related mechanism of Euphorbia factor L2 with...
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ورودعنوان ژورنال:
- Molecules
دوره 16 4 شماره
صفحات -
تاریخ انتشار 2011